The small differences in lifestyle between the two groups could not explain these findings. We found a negative effect of smoking on serum osteocalcin ( P=0.01), while urinary pyridinolines were similar in the two groups. There was no difference in serum ionized calcium between smokers and non-smokers. Results: Fifty percent were current smokers.

Multiple regression analyses were performed to detect the effect of potentially confounding lifestyle factors, such as calcium and vitamin D intakes, alcohol and coffee consumption, sunbathing, and physical exercise. Bone mineral density (BMD) was measured with DEXA-scans. The two groups were compared with regard to serum levels of 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25-(OH) 2D), intact PTH, ionized calcium and phosphate, osteocalcin, as well as urine pyridinolines. Methods: The women were grouped according to their current smoking status. None were using hormone replacement therapy. Subjects: Five-hundred-and-ten healthy women aged 45–58 y, included 3–24 months after last menstrual bleeding.

Objective: To assess the influence of smoking on serum parathyroid hormone (PTH), serum vitamin D metabolites, serum ionized calcium, serum phosphate, and biochemical markers of bone turnover in a cohort of 510 healthy Danish perimenopausal women.

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